‘The Centre d’Etude du Polymorphisme Humain (CEPH), founded by Jean Dausset (Nobel Prize for Medicine 1980) in 1984, is a French organisation dedicated to genetic research. CEPH is an international reference for its role in initiating and advancing the mapping of the human genome in the 1990s. This major scientific breakthrough, subsequently consolidated by numerous contributions to major international and national scientific projects, has given the CEPH great expertise in the creation of large collections of biological samples, high-quality molecular extractions (DNA and RNA) and their safe storage. This experience has enabled the CEPH to be selected as part of the Equipex+ BioCF, funded by the Plan Investissement d’Avenir launched in 2020 by the French Ministry of Research. This Equipex+ aims to provide the CEPH with precise, complex and expensive equipment that will enable it to establish large-scale scientific partnerships and participate in major research consortia. The CEPH mainly hosts the biological collections and their molecular derivatives of several national cohorts from the general population (Constances, Gazel, E3N-E4N, Elfe and Epipage 2), the elderly and cancer patients (breast, bladder, lung).